• br Results br Discussion Here we have

  2018-11-08

  

  Results Discussion Here, we have shown that GATA4, MEF2C, TBX5, ESRRG, MESP1, MYOCD, and ZFPM2 together reprogram human fibroblasts toward a CM-like state. Human iCMs upregulated hundreds of CM-enriched genes, downregulated hundreds of fibroblast-enriched transcripts, and assembled sarcomeres.

• PMX 205 Our observations are consistent with previous findi

  2018-11-08

  

  Our observations are consistent with previous findings in vivo that Ahr expression is silenced at the 2-cell stage, becoming again detectable in late blastocysts (Peters and Wiley, 1995; Dey and Nebert, 1998; Wu et al., 2002) and in most developing organs during post-implantation development (Abbott

• In summary we confirm that HB F CD and HB

  2018-11-08

  

  In summary, we confirm that HB1.F3.CD and HB1.F3.CD.IFN-β buspirone hcl selectively migrated toward breast cancer cells. This is likely due to various chemokines expressed by the tumor cells and their cognate receptors expressed on the stem cells, such as SCF/c-kit and VEGF/VEGFR2, respectively. Th

• br Materials and methods br Results br Discussion In

  2018-11-08

  

  Materials and methods Results Discussion In these experiments, we sought to determine the influence of gravitational mechanical unloading on the regenerative ability of bone marrow progenitors and specifically hypothesized that exposure to microgravity may alter the differentiation of bone

• Although the expression of bisect type N

  2018-11-08

  

  Although the norepinephrine bitartrate of bisect-type N-glycans during neuronal differentiation was significantly up-regulated, this did not occur during glial differentiation. This result indicates that increased bisect-type N-glycan expression is specific to neuronal differentiation. Therefore, b

• HSCs isolated by the set of markers which

  2018-11-08

  

  HSCs isolated by the set of markers which are Lin−/Sca-1+/C-kit+ (LSK) have been also reported to be heterogeneous (Osawa et al., 1996). Moreover, Sca-1 expression differs between mouse strains and therefore is not very effective to enrich HSCs (Spangrude and Brooks, 1993). Likewise, the SLAM family

• Subsequently these expanded effector cells

  2018-11-08

  

  Subsequently, these expanded effector 10058-F4 were examined for their cytotoxicity activity (PI% and LDH release) against targets, where they also showed strong killing of the K562 leukemia cell line. However, the observation of the slight cytotoxicity induced by fresh effector cells suggests prope

• Main Text We appreciate the

  2018-11-08

  

  Main Text We appreciate the interest that Andersen et al. (2014) have shown in our work on neonatal cardiac regeneration. Their recent paper relates directly to resection methodology first presented by Porrello et al. (2011) and describes a failure to reproduce the observations made in that study r

• One of these closely related model

  2018-11-08

  

  One of these closely related model organisms is the old world monkey Macaca (mulatta or fasicularis), which follows a Carnegie staging system that is highly correlated with the timing of human development, particularly in the beginning (Fig. 1). Notably, formation of the primitive streak in macaques

• secretin receptor Multi electrode array approaches have been

  2018-11-08

  

  Multi-electrode array approaches have been proposed as a tool for detecting functional changes in electrically excitable cells, including neurons, exposed to drugs or toxins and allow use in high throughput studies (McConnell et al., 2012). Although there are a number of electrophysiological measure

• Growth factors such as BMP

  2018-11-08

  

  Growth factors such as BMP-4 initiate the commitment of pluripotent stem ABT-737 to the mesodermal lineage (Winnier et al., 1995). It is not known how a single growth factor such as BMP-4 activates the extensive transcriptional program required for mesodermal commitment. Our finding that overexpres

• In this work we developed multiple tools

  2018-11-08

  

  In this work, we developed multiple tools to interrogate this autocrine and paracrine signaling loop involving α-5 laminin production by hPSCs. The use of the inducible short hairpin lines allowed us to control the dynamics of α-5 laminin production in a reversible manner. However, the interpretatio

• The next goal for gene therapy is the directed insertion

  2018-11-08

  

  The next goal for gene therapy is the directed insertion of the therapeutic sequences in the cell genome (Garate et al., 2013; Genovese et al., 2014; Karakikes et al., 2015; Song et al., 2015). A number of different gene-editing strategies have been described, including gene modification of the spec

• br Experimental Procedures br Author Contributions All autho

  2018-11-08

  

  Experimental Procedures Author Contributions All authors fulfill the ICMJE guidelines for authorship. E.B.B., Y.L.T., Y.P.P., S.L., H.S.C., Q.D., and S.-B.J. performed the biological experiments. Y.L.T. and D.R. performed the bioinformatics part of the study. A.L., X.L., C.S., S.-B.J., and U.L

• In the present study we explored

  2018-11-07

  

  In the present study, we explored the effects of coinheritance of HbAS and α+thalassemia on a range of phenotypes that are believed to be associated with the pathogenesis of severe and complicated malaria, including cytoadhesion, rosetting and PfEMP1 expression. We found that pRBCs from donors with

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