• The year marks the birth of one of the most

  2018-11-06

  

  The year 1889 marks the birth of one of the most significant landmarks of all Expo history. La Dame de Fer – as it was named – was conceived as a gigantic folly (300m high) at the center of the park outside of the several national pavilions of the main exposition building. Originally seen as somethi

• br Results Compared with less active participants site

  2018-11-06

  

  Results Compared with less active participants, site walkability was rated significantly higher among the participants who had engaged in physical activities at least one time per day or at least ten minutes per occurrence (p Discussion Introduction The environment consists of many elements

• br City Prosperity Manifest Cities

  2018-11-06

  

  City Prosperity Manifest Cities have been perceived as the engines of a country׳s economy, creativity, well-being, and development. For decades, economic growth was considered the key factor to development policies. However, city prosperity currently looks beyond this perspective and examines how

• Our finding that Eng plays

  2018-11-06

  

  Our finding that Eng plays a significant role in the EC specification is consistent with the published data that support a role of Eng in vascular development (ten Dijke and Arthur, 2007) and angiogenesis (ten Dijke et al., 2008). It is also consistent with the recent finding that ERG1 induces Eng e

• An interesting remaining question is whether hemogenic endot

  2018-11-06

  

  An interesting remaining question is whether hemogenic endothelial cells are already committed to producing blood or whether any endothelial cell is capable of doing so depending on the influence of a singular environment. It is of interest to note that hemogenic endothelial cells found in different

• Although the concept of direct

  2018-11-06

  

  Although the concept of direct interference with the genetic and molecular foundation of cardiac cmv virus is simple and elegant, myocardial gene transfer is difficult to achieve as a clinical reality. While the use of certain vectors ensures durable release of VEGF without genome integration, thes

• br Materials and methods br Results

  2018-11-06

  

  Materials and methods Results There are a number of complex methods for the generation of neural subtypes from hESCs and iPSCs. In most of them, intact pluripotent colonies are first lifted, induced to form EBs, and then grown in the presence of lineage specific morphogens and growth factors t

• br Microarray based transcriptome analysis Total RNA was iso

  2018-11-06

  

  Microarray-based transcriptome analysis Total RNA was isolated for each sample. For global gene expression analysis on an Illumina microarray platform quality-checked total RNA was used. 500ng RNA for each sample was used. The cRNA synthesis, BeadChip hybridization and scanning were performed by

• While i n administered MSCs were clearly detected

  2018-11-06

  

  While i.n-administered MSCs were clearly detected in the lungs of normal mice, and to a greater extent, the inflamed lungs of mice with chronic AAD 48h later, previous studies in murine models of kidney disease (Huuskes et al., 2015; Togel et al., 2008) had shown that these pelitinib could not be d

• br Design of donor plasmids If no footprintless gene

  2018-11-06

  

  Design of donor plasmids If no footprintless gene targeting is required or it is intended to introduce larger transgenes, donor plasmids have to be constructed that contain the homology arms flanking the transgenes or selection cassettes coupled to promoters of choice. Similarly, donor plasmids c

• To examine the functional role

  2018-11-06

  

  To examine the functional role of IGFBP-2 and -3 we conducted the experiments described in Fig. 4 where the effects of IGFBP-2 and -3 were examined either uncomplexed or complexed with IGF1. The data indicated that IGF1 stimulated ALP activity in DPCs in a dose dependant manner and although there we

• br Experimental Procedures br Acknowledgments We are gratefu

  2018-11-05

  

  Experimental Procedures Acknowledgments We are grateful to Y. Saga (Nanos3), H. Enomoto (Gdnf), H. Sasaki (T), T. Fujimori (R26R-H2B-mCherry), and J. Miyazaki (CAG-CAT-EGFP) for the use of the mice indicated, and to T. Ishitani for the TCF-luc plasmid. We also thank T. Fujimori, M. Tanaka, R.

• To inspect the motion of a particle in bent

  2018-11-05

  

  To inspect the motion of a particle in bent crystals, the old coordinates of the points (x, y, z) in the simulated boxes are transformed into new (x′, y′, z′) by the following rule: where the parameter defines the shape of a bent crystal. The latter equation holds for a bending radius that suffici

• br Introduction Studying the temperature dynamics of the

  2018-11-05

  

  Introduction Studying the temperature dynamics of the mechanical properties of p38 inhibitor is important for solving the problems of cryobiology, a field concerned with the behavior of cells and tissues at low temperatures [1,2]. These properties of the plasma membrane influence the mechanism b

• The results are in line

  2018-11-05

  

  The results are in line with other studies concerned with long-term mortality effects of critical life events based on Finnish register data. People born during the famine in the 1860s (Kannisto, Christensen, & Vaupel, 1997), male cohorts who fought in World War II (Saarela and Finnäs, 2010), and pe

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