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Apelin is involved in various physiological functions includ
2023-12-20
Apelin is involved in various physiological functions, including Repaglinide contraction (Ashley et al., 2005), vasodilatation (Jia et al., 2007), feeding control (Valle et al., 2008), and metabolic homeostasis (Higuchi et al., 2007, Dray et al., 2008, Attane et al., 2010). Its plasma level is eleva
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br Concluding remarks br Conflict of interest br Acknowledgm
2023-12-20
Concluding remarks Conflict of interest Acknowledgment This work was supported by the H.E.B. Endowed Chair in Marine Science (to P.T.) and University of Texas Marine Science Institute endowment-supported scholarships (to A.C). Introduction Disorders of sex development (DSD) are defined
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br Experimental procedures br Results br
2023-12-20
Experimental procedures Results Discussion Acknowledgments SRE and EBL contributed equally to this (-)-Bicuculline methiodide work. SRE, EBL, and MJT designed experiments, SRE, EBL, MCH, and AEI conducted experiments, SRE and EBL analyzed data, and EBL and MJT wrote the manuscript. We w
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A disfun o cognitiva p s operat ria uma
2023-12-20
A disfunção cognitiva pós‐operatória é uma síndrome perioperatória bem reconhecida, consequência da anestesia e cirurgia cuja causa exata permanece por esclarecer. De que forma carboxypeptidase disfunção cognitiva pós‐operatória e a doença de Alzheimer podem estar ligadas permanece uma questão em es
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br Methods br Results br Discussion Chronic stress renders i
2023-12-20
Methods Results Discussion Chronic stress renders individuals vulnerable to diseases, and this effect might be, at least partially, mediated by stress hormone-induced immunosuppression. Therefore, investigating the effects of catecholamines on immune BET bromodomain inhibitor is of high re
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ARRY-142886 Adiponectin also suppresses inflammatory stimuli
2023-12-20
Adiponectin also suppresses inflammatory stimuli-induced NF-kappaB activation, which may significantly contribute to the anti-diabetic and anti-atherogenic effects of adiponectin (Ouchi et al., 2000). The downstream mediators of AdipoR1 and AdipoR2, RPPAR and AMPK increase inflammatory responses by
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br Materials and methods br Results The determination of the
2023-12-20
Materials and methods Results The determination of the intrinsic inhibitory potential of the oximes HI-6 and MMB-4 with human and guinea pig AChE revealed marked differences between both oximes (Table 1). MMB-4 had an only marginal effect on both AChE species, calculated IC50 of >1000μM, while
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The reductase family is composed of three known isozymes
2023-12-19
The 5α-reductase family is composed of three known isozymes, with the types I and II being the most known. Type I isozyme, which is the dominant form, can be found in the skin, liver, kidney, brain and lung. Furthermore, it has been evidenced that type I activity is several times higher in PC than i
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br Disclosure br Acknowledgement br
2023-12-19
Disclosure Acknowledgement Introduction CYP17A1 is a multifunctional enzyme with both 17α-hydroxylase and 17,20-lyase activities and is essential for the biosynthesis of steroidal Bax inhibitor peptide V5 in male testes and adrenal glands. The 17α-hydroxylase activity of CYP17A1 is involved
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br Innate immune mechanisms that confront viral infection br
2023-12-19
Innate immune mechanisms that confront viral infection Autophagy induction by virus sensing Antiviral xenophagy and virophagy The presence of viral particles within autophagosomal structures has been visualized in only rare instances. This is the case for HSV-1 when it is devoided of ICP34.
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br Colorectal carcinoma The growth rate of murine colon
2023-12-19
Colorectal carcinoma The growth rate of murine colon adenocarcinoma tumors decreased upon inhibition of 5-LOX, an enzyme that harbors counteracting properties to 15-LOX [28]. It is not clear whether 15-LOX was associated with this phenomenon, but its expression is induced in the colon carcinoma c
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Protein phosphorylation is an important posttranslational
2023-12-19
Protein phosphorylation is an important posttranslational mechanism for the regulation of distribution, trafficking, and function of modified proteins (Wang et al., 2014). GluA1 phosphorylation at S845 also has functional consequences (Lu and Roche, 2012). For instance, S845 phosphorylation drove tr
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We demonstrated clearly that the overexpression of sFlt
2023-12-19
We demonstrated clearly that the overexpression of sFlt-1 significantly increased arginase AGK7 sale and enhanced arginase activity in HUVECs (Fig. 3). NO formation is related inversely to serum levels of sFlt-1 in preeclampsia [11]. The disorder of NO formation, which was involved in hypertension a
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Furthermore we also found that the
2023-12-19
Furthermore, we also found that the basic level of ROS was markedly lower in mtDNA-reduced SW480 fbpase than that in the parent cells. Endogenous ROS is most notably produced at the sites of complex I and complex III [5], it might be plausible that the decreased quantity of ROS observed in mtDNA-re
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Therefore in the present study we first examined the ATRAP
2023-12-19
Therefore, in the present study, we first examined the ATRAP ER 50891 in human leukocytes of healthy subjects. We next analyzed possible relevant clinical factors affecting ATRAP expression in leukocytes of patients with NCDs. Furthermore, we examined the possible effect of ATRAP downregulation on t
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