• Taken together the results reveal a complex feedback and

  2025-01-15

  

  Taken together, the results reveal a complex feedback and feedforward signaling network between the tryptophan metabolic enzymes IDO1/TDO2, the KP metabolite KYN, and the ligand-activated transcription factor AhR (Figure 2). Cancer Angiotensin 1/2 (1-5) highjack this signaling circuitry to deregulat

• Amyloid peptide fragment br Material and methods br Results

  2025-01-15

  

  Material and methods Results Discussion Neurotransmitters pathways within vertebrates, including fish, are well conserved (Kreke and Dietrich, 2008, Valenti et al., 2012). Therefore psycopharmaceuticals that are design to act on these pathways in mammals, will possibly interact with the sam

• Materials and methods br Results br Discussion

  2025-01-14

  

  Materials and methods Results Discussion The BV-tag-based electrochemiluminescence immunoassay is an extremely sensitive assay. It has been employed for detecting analytes present in only picogram quantities (e.g., bacterial toxins [26], Breast carcinoma therapy [19]), measuring the activity

• Caffeic acid dihydroxycinnamic acid is a natural compound

  2025-01-14

  

  Caffeic Cy3.5 fluorescent dye (3,4-dihydroxycinnamic acid) is a natural compound that inhibits 5-LO and exerts potent anti-inflammatory and antioxidant properties. Recently, Takeda et al. reported that caffeic acid provided neuroprotective and anti-depressive activities [23]. Sertraline, a selective

• Vortioxetine is a multimodal antidepressant that

  2025-01-14

  

  Vortioxetine is a multimodal antidepressant that acts as an inhibitor at the serotonin (5-HT) transporter (SERT), an agonist at 5-HT1A receptors, a partial agonist at 5-HT1B receptors, and an antagonist at 5-HT1D, 5-HT3 and 5-HT7 receptors (Bang-Andersen et al., 2011, Sanchez et al., 2015). Based on

• The most potent compounds within the

  2025-01-14

  

  The most potent compounds within the current series of compounds were therefore , , , , and , with RN486 possessing the best selectivity towards the lyase reaction in comparison to the hydroxylase reaction, indeed, this compound was found to possess an IC value of 1210nM against the 17α-OHase com

• Herein we disclose novel dihydropyrano c pyrazoles that inhi

  2025-01-14

  

  Herein, we disclose novel 2,4-dihydropyrano[2,3-c]pyrazoles that inhibit human ATX (hATX). Our results demonstrate and further support previous findings showing that a desired biological action can be achieved without targeting the catalytic site of the enzyme. Moreover, this study validated hen egg

• br Discussion Herein we demonstrate that

  2025-01-14

  

  Discussion Herein, we demonstrate that mice deficient in L-12/15 LO are more sensitive to 3-NP-induced toxicity although a substantial individual variability in striatal lesion size in response to 3-NP in both genotypes was observed. This variability is not atypical; several studies demonstrate

• Consistent with the in vitro results memantine ameliorated A

  2025-01-13

  

  Consistent with the in vitro results, memantine ameliorated Aβ-induced cytotoxicity in rat primary cortical cultures. Studies reported that memantine protected neurons against the damage caused by aggregated Aβ40 or Aβ42 oligomers in vivo[26], [27]. These results suggest that, in addition to its neu

• Clinical observations of individuals with a decrease in

  2025-01-13

  

  Clinical observations of individuals with a decrease in 12-LOX nuciferine are consistent with 12-LOX potentiating platelet activation and thrombus formation [40]. However, the relative contribution of 12-LOX to these complex disorders cannot be fully elucidated in the absence of a biochemical asses

• Introduction Inflammasomes are large cytosolic protein compl

  2025-01-13

  

  Introduction Inflammasomes are large cytosolic protein complexes with multiple components that trigger a rapid immune response against pathogen-associated molecular pattern Pseudochelerythrine chloride (PAMPs) during pathogen infections or damage-associated molecular pattern molecules (DAMPs) durin

• Peficitinb In this study we demonstrated that DRR protein le

  2025-01-13

  

  In this study, we demonstrated that DRR1 protein level in GBM tissues was significantly higher compared to normal Peficitinb tissues. This data suggested that DRR1 might play a role in the tumorigenesis of glioma. To investigate whether DRR1 could accurately predict the outcome in patients with gli

• sphingosine kinase inhibitor Targeted disruption of the Akt

  2025-01-13

  

  Targeted disruption of the Akt1 gene in mice induces a growth retardation phenotype [4,19]. Akt2 KO mice reveal mild growth retardation and insulin resistance [4,20,21]. Akt1/2 double KO (DKO) mice display severe growth deficiency and die shortly after birth. These mice exhibit impaired bone and ski

• br Transparency document br Introduction G protein coupled r

  2025-01-13

  

  Transparency document Introduction G protein-coupled receptors (GPCRs) comprise a diverse family of seven transmembrane domain-containing receptors represented by over 800 genes in humans. GPCRs respond to a range of stimuli, including peptides, hormones, growth factors, lipids, odorants, and

• Human testicular peritubular cells HTPCs

  2025-01-13

  

  Human testicular peritubular monocarboxylate transporters (HTPCs) are also the only human testicular cell type that can be isolated, cultured and studied in vitro (Albrecht et al., 2006, Mayerhofer, 2013). Results from recent studies indicate that their roles go beyond sperm transport and include im

16607 records 33/1108 page Previous Next First page 上5页 3132333435 下5页 Last page