• Studies utilising GPR mice however

  2022-04-06

  

  Studies utilising GPR55−/− mice, however, report different effects of GPR55 on body weight and insulin sensitivity. Genetic deletion of GPR55 appears to have no effect on overall body weight 5, 6, 7. However, one of these studies found increased fat deposition and insulin resistance in GPR55−/− mice

• LPC OMe LPC LPC and OMe LPC were

  2022-04-06

  

  LPC 14:0, 2-OMe-LPC 14:0, LPC 16:0 and 2-OMe-LPC 16:0 were shown to be most potent stimulators of intracellular calcium flux in the β cell model, which is one of key processes leading to insulin exocytosis. Yet, species with myristoyl residue initiate calcium influx through voltage-gated i thought a

• We found that most antigenic regions

  2022-04-06

  

  We found that most antigenic regions in GlyT1C are located in the second half of the GlyT1C-terminus, which is in concert with previously published results (Olivares et al., 1994). We however further show that in contrast to epitopes 554–625 which are affected by calcium only minimally, the epitopes

• br Material and methods br Results br Discussion Neurosteroi

  2022-04-06

  

  Material and methods Results Discussion Neurosteroids capable of blocking the NMDAR channel attract a lot of attention as possible therapeutic agents for the treatment of neurodegenerative diseases. A large number of new Meptazinol HCl sale with different structures have been synthesized i

• The mechanism underlying the anorectic effect of OXM is

  2022-04-06

  

  The mechanism underlying the anorectic effect of OXM is well established. It is centrally mediated via GLP-1 receptor activation, confirmed by both pharmacological blockade of the GLP-1 receptor, and using GLP-1 receptor knock-out mice [2], [11], [12]. However, the mechanism by which it increases en

• Fmoc-Arg(Pbf)-OH Although several new elements i

  2022-04-06

  

  Although several new elements (i.e., microsomes and NADPH) were added in E. coli cultures in the current study, the concentration of LacZ gene inducer, IPTG, to stimulate for the maximum production of β-galactosidase enzyme at media pH of 7.0 was observed to be the same as in the previous study (Fig

• In the course of our ongoing

  2022-04-06

  

  In the course of our ongoing attempts to photolabel allosteric binding sites of γ-aminobutyric Fmoc-D-Lys(Boc)-OH synthesis type A (GABAA) receptors, we were met with the need for relatively large (near mg) quantities of recombinant protein. Rather than establishing a stable cell line we sought to o

• The aims of the present

  2022-04-01

  

  The aims of the present study were to further investigate the localisation of glycine and GABAA receptors on individual neurons and how closely these two receptor types were associated with each other by carrying out double immunofluorescent labelling and imaged using confocal laser scanning microsc

• 2-Phenyl-2-(1-piperidinyl)propane australia br Materials and

  2022-04-01

  

  Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast 2-Phenyl-2-(1-piperidinyl)propane australia by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity

• br Methods br Acknowledgements The authors thank the

  2022-04-01

  

  Methods Acknowledgements The authors thank the ZLS group members, particularly Li Li and Elijah Roberts, for many helpful discussions. They also wish to thank Nathan Baker for APBS assistance, Jan Jensen for help with PROPKA 2.0, Susan Martinis for experimental interpretations, and John Stone

• br Acknowledgments This research was supported by

  2022-04-01

  

  Acknowledgments This research was supported by a grant from the Korea Health Technology R&D Project through the Korean Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI17C0616). Dr. Jun-Mo Yang was supported by the Natio

• br GLP R expression in the

  2022-04-01

  

  GLP-1R expression in the vascular endothelium Immunohistochemistry studies utilizing GLP-1R antibodies that have now been demonstrated to be non-specific [46], initially identified GLP-1R protein expression in both mouse mesenteric artery SMCs and heart coronary SMCs [7]. However, evidence for VS

• Piezo channels can be activated by many mechanical stimuli W

  2022-04-01

  

  Piezo channels can be activated by many mechanical stimuli . While some of these stimulations directly mimic physiological forces experienced by cam kinase ii , such as shear stress applied in a microfluidic chamber, the most commonly used modes of stimulation consist of stretching the membrane by

• Although NCT undergoes complex glycosylation processing for

  2022-04-01

  

  Although NCT undergoes complex glycosylation processing for maturation through trafficking from endoplasmic reticulum to Golgi or additional compartments, the effect of NCT glycosylation on γ-secretase activity and substrate specificity is still unknown. The present study focused on glycosylation st

• br The interrelationship between obesity

  2022-04-01

  

  The interrelationship between obesity and galanin Numerous studies revealed that obesity and galanin may promote each other. On the one hand, galanin may increase the possibility of obesity of subjects via boosting their appetite and food intake. Acute injection with galanin or its agonist, galan

16542 records 487/1103 page Previous Next First page 上5页 486487488489490 下5页 Last page