• Introduction Induction of long term potentiation LTP

  2024-07-11

  

  Introduction Induction of long-term potentiation (LTP), the cellular correlate of learning and memory, triggers profound changes in the structure and function of excitatory synapses by increasing dendritic spine size and synaptic strength. Significant progress has been made in understanding the int

• br Results br Discussion By using an unbiased proteomic scre

  2024-07-11

  

  Results Discussion By using an unbiased proteomic screen for xCT binding partners, followed by functional validation, we have made the surprising discovery that mTORC2 regulates amino AGI5198 metabolism in tumor cells by phosphorylating serine 26 of the cystine-glutamate antiporter xCT on its

• A disfun o cognitiva p s operat

  2024-07-11

  

  A disfunção cognitiva pós‐operatória é uma síndrome perioperatória bem reconhecida, consequência da anestesia e cirurgia cuja causa exata permanece por esclarecer. De que forma Concanamycin A disfunção cognitiva pós‐operatória e a doença de Alzheimer podem estar ligadas permanece uma questão em estu

• br Funding This work was supported by

  2024-07-10

  

  Funding This work was supported by Arena Pharmaceuticals, Inc, San Diego, CA, USA. Introduction 5-hydroxytryptamine 1B (5-HT1B) receptors are widely distributed in the central nervous system (CNS); they have various modulatory functions in drug reinforcement, appetitive behaviors, stress, moo

• Metformin s pluripotent roles are alluded to in terms

  2024-07-10

  

  Metformin's pluripotent roles are alluded to in terms of its antitumorigenic, glucose-lowering, and cardioprotective effects, which are due in part to its upregulation of AMPK activity [39,40]. Metformin's glucose-lowering effect is a result of reduced hepatic gluconeogenesis, whereas improved insul

• MicroRNA miRNA is an abundant group of small

  2024-07-10

  

  MicroRNA (miRNA) is an abundant group of small (22-nucleotide) noncoding RNA molecules that directly binds with 3′ untranslated region (UTR) of target messenger RNAs (mRNAs) to regulate gene expression, playing an important role in variety of biological processes including cell proliferation, apopto

• tryptophan hydroxylase br Methods and results ACE is

  2024-07-10

  

  Methods and results ACE is a Canadian satellite mission [7] that measures atmospheric tryptophan hydroxylase spectra in the limb geometry using the Sun as a light source (solar occultation). The ACE orbit (74° inclination to the equator, 650 km altitude) concentrates measurements at high latitud

• br LOX in pancreatic cancer LOX

  2024-07-10

  

  5-LOX in pancreatic cancer 5-LOX is a key player in pancreatic cancer (PC) progression. The upregulation of 5-LOX mRNA has been observed in pancreatic adenocarcinoma (PDAC) and also in neoplastic pancreatic tissues (Kennedy et al., 2003). Higher levels of 5-LOX transcripts (messengers) are presen

• br Materials and methods br

  2024-07-10

  

  Materials and methods Results Discussion Prostate cancer represents an ideal candidate for chemoprevention because of its high incidence and long latency to clinically significant disease [17]. The precancerous lesion PIN may also be a suitable target for ablation in chemoprevention strateg

• The exact etiology of BPH is not completely understood howev

  2024-07-10

  

  The exact etiology of BPH is not completely understood, however this pathology has been associated with elevated ionophore levels of the androgen DHT (10). Thus, a valuable strategy in BHP treatment is the reduction of DHT (10) levels, by inhibiting its biosynthetic production [6], [8]. An importan

• br Contemporary understanding for alcoholic cardiomyopathy U

  2024-07-10

  

  Contemporary understanding for alcoholic cardiomyopathy Up-to-date, a number of theories are postulated for alcoholic cardiomyopathy including generation of mitochondrial reactive oxygen species (ROS), oxidative stress, neurohormonal overactivation (catecholamines and angiotensin II), apoptosis a

• Based on currently available knowledge autophagy supports ad

  2024-07-10

  

  Based on currently available knowledge, autophagy supports adipocytes development and differentiation. In animals with specific skeletal muscle beta-lactamase of Atg7, reduced adipogenesis was shown. In rodents, autophagy was decreased in adipose tissue of animals fed with high-fat diet (HFD). In c

• Here we report discovery of highly selective

  2024-07-10

  

  Here we report discovery of highly selective pan-Aurora kinase inhibitors through phenotypic screening. The co-crystal structure of acetylcholine receptor bound in the ATP binding site of Aurora A is described, and provides insight into the possible structural basis for the selectivity of the intera

• Recruitment of the Rad BP mediator to

  2024-07-10

  

  Recruitment of the Rad9/53BP1 mediator to resveratrol mg involves multiple pathways (Fig. 2). In unperturbed conditions, Rad9 is already bound to chromatin via interaction between its Tudor domain and methylated histone H3 at lysine 79 [82], [83], [84], [85]. This constitutive Rad9 recruitment to ch

• Molecular docking quantitative structure activity relationsh

  2024-07-10

  

  Molecular docking, quantitative structure–activity relationship (QSAR) and high-throughput virtual screening (HTVS) studies have a very widespread use in computer-assisted drug design.25, 26, 27, 28 Suvannang et al. used the published X-ray crystallographic data to examine known aromatase inhibitors

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