• A significant issue that has

  2020-07-31

  

  A significant issue that has limited the biochemical characterization of the E1 helicase to only a few PV types has been the difficulty in expressing and purifying large quantities of the protein in a recombinant form that can support cell-free DNA replication. This is in part due to the fact that E

• In addition to supporting the catalytic

  2020-07-31

  

  In addition to supporting the catalytic function of BRCC36, KIAA0157 and Abraxas also serve scaffolding functions to recruit the BRCC45–MERIT40 heterodimer and the targeting subunits RAP80 or SHMT2. Surprisingly, super dimerization is not only required for the catalytic function of BRCC36 but it is 

• Up to the date of writing there are no published

  2020-07-31

  

  Up to the date of writing, there are no published clinical studies that would have compared treatment outcome of GBM patients after radiotherapy depending on tumor PARP-1 and DNA-PK expression levels. Therefore, the data of the present study cannot be compared with similar studies. In spite of that,

• Introduction Maintenance of genome integrity is essential fo

  2020-07-31

  

  Introduction Maintenance of genome integrity is essential for life, and faithful DNA replication and repair ensure this. One of the most important parameters for DNA maintenance is the regulation of optimal concentrations of the four 5′-deoxyribonucleoside-triphosphates (dNTPs) the precursors for D

• br Introduction DNA damage repair is essential life processe

  2020-07-31

  

  Introduction DNA damage repair is essential life processes for maintaining the integrity and stability of genomic DNA, in which many enzymes, bio-molecules and ribozymes participate (Friedberg, 2003, Sancar et al., 2004, McCabe et al., 2006). In particular, the ligation reaction of 5′-phosphate a

• In this study we measured the MGK and MGK

  2020-07-31

  

  In this study, we measured the 1-MGK and 2-MGK activities of all ten DGK isozymes. We revealed that the type I DGKs (α, β and γ), type II DGKs (δ, η and κ) and type III DGK (ε) have 8–19% 2-MGK activity compared to their DGK activities, whereas their 1-MGK activities were BI 6015 beyond our expecta

• br Results and discussion Our

  2020-07-31

  

  Results and discussion Our group has previously explored the binding cavity of Pf-DHFR against 185 diverse natural products using AutoDock (Kumar et al., 2014). Interestingly, all the xanthones displayed strong binding interactions with hydrophobic lining of binding cavity. Another very important

• br Patients and methods br Results Table shows

  2020-07-31

  

  Patients and methods Results Table 1 shows relevant demographic and clinical characteristics of the 123 patients in the cohort. BAL fluid samples were obtained at a median of 172.5 days after allo-HSCT (range 3 days to five years). Discussion The definitive abandonment of traditional cultu

• br Casein Kinase II CK

  2020-07-31

  

  Casein Kinase II (CK2) Casein Kinase II (CK2) is a ubiquitous serine/threonine-selective pro-oncogenic protein kinase that has become a more prominent target for research due to its effects and key role in tumorigenesis (Gowda et al., 2017a, Pinna, 2002). CK2, a well-conserved, pleiotropic kinase

• Hepatitis E is a major public

  2020-07-30

  

  Hepatitis E is a major public health issue, especially in developing countries, and is caused by infection with the Hepatitis E virus (HEV) (Aggarwal and Krawczynski, 2000; Sridhar et al., 2015). The HEV genome consists of three open reading frames (ORFs), of which the ORF2 encodes the virus capsid

• Furthermore our sample preparation uses a simple isolation

  2020-07-30

  

  Furthermore, our sample preparation uses a simple isolation procedure. Numerous CYP450 phenotyping methods employed extensive extraction procedures for sample preparation such as dual liquid extraction or solid phase extraction which are costly and time consuming [10], [17], [18], [19], [20], [23],

• br Materials and methods br

  2020-07-30

  

  Materials and methods Results Table 1 shows the clinical data of the 63 recipients. They comprised 23 recipients with CYP3A5*1 allele (CYP3A5*1/*1 or *1/*3) and 40 recipients without CYP3A5*1 allele (CYP3A5*3/*3). Plasma concentration (mean ± SD) of 4β-hydroxycholesterol was 36.4 ± 11.7 ng/mL;

• CDK inhibitors do not only target

  2020-07-30

  

  CDK inhibitors do not only target the cell proliferation machinery, but they can also inhibit tumor-promoting inflammation. The vast majority of all cancers are caused by somatic mutations and environmental factors such as inflammation 76, 77, 78. Inflammatory conditions occur before a malignant cha

• The finding that C forms a

  2020-07-30

  

  The finding that C75 forms a CoA adduct before it can inhibit CPT1 is reminiscent of the case of etomoxir. McGarry and co-workers [43], [44] showed that the CPT1 inhibitory molecules were neither tetradecylglycidic T7 Tag Peptide nor etomoxir themselves, but rather their CoA esters produced in the

• Furosemide Michel et al calculated the mutual solubilities o

  2020-07-30

  

  Michel et al. [34] calculated the mutual solubilities of water and hydrocarbons by a cubic equation of state. They asserted that Furosemide conventional mixing rules can not satisfactorily describe the hydrogen bonding compounds. Kabadi and Danner [35] applied a modified form of Soave-Redlich-Kwong

15821 records 789/1055 page Previous Next First page 上5页 786787788789790 下5页 Last page