• Subsequently these expanded effector cells

  2018-11-08

  

  Subsequently, these expanded effector 10058-F4 were examined for their cytotoxicity activity (PI% and LDH release) against targets, where they also showed strong killing of the K562 leukemia cell line. However, the observation of the slight cytotoxicity induced by fresh effector cells suggests prope

• Main Text We appreciate the

  2018-11-08

  

  Main Text We appreciate the interest that Andersen et al. (2014) have shown in our work on neonatal cardiac regeneration. Their recent paper relates directly to resection methodology first presented by Porrello et al. (2011) and describes a failure to reproduce the observations made in that study r

• One of these closely related model

  2018-11-08

  

  One of these closely related model organisms is the old world monkey Macaca (mulatta or fasicularis), which follows a Carnegie staging system that is highly correlated with the timing of human development, particularly in the beginning (Fig. 1). Notably, formation of the primitive streak in macaques

• secretin receptor Multi electrode array approaches have been

  2018-11-08

  

  Multi-electrode array approaches have been proposed as a tool for detecting functional changes in electrically excitable cells, including neurons, exposed to drugs or toxins and allow use in high throughput studies (McConnell et al., 2012). Although there are a number of electrophysiological measure

• Growth factors such as BMP

  2018-11-08

  

  Growth factors such as BMP-4 initiate the commitment of pluripotent stem ABT-737 to the mesodermal lineage (Winnier et al., 1995). It is not known how a single growth factor such as BMP-4 activates the extensive transcriptional program required for mesodermal commitment. Our finding that overexpres

• In this work we developed multiple tools

  2018-11-08

  

  In this work, we developed multiple tools to interrogate this autocrine and paracrine signaling loop involving α-5 laminin production by hPSCs. The use of the inducible short hairpin lines allowed us to control the dynamics of α-5 laminin production in a reversible manner. However, the interpretatio

• The next goal for gene therapy is the directed insertion

  2018-11-08

  

  The next goal for gene therapy is the directed insertion of the therapeutic sequences in the cell genome (Garate et al., 2013; Genovese et al., 2014; Karakikes et al., 2015; Song et al., 2015). A number of different gene-editing strategies have been described, including gene modification of the spec

• br Experimental Procedures br Author Contributions All autho

  2018-11-08

  

  Experimental Procedures Author Contributions All authors fulfill the ICMJE guidelines for authorship. E.B.B., Y.L.T., Y.P.P., S.L., H.S.C., Q.D., and S.-B.J. performed the biological experiments. Y.L.T. and D.R. performed the bioinformatics part of the study. A.L., X.L., C.S., S.-B.J., and U.L

• In the present study we explored

  2018-11-07

  

  In the present study, we explored the effects of coinheritance of HbAS and α+thalassemia on a range of phenotypes that are believed to be associated with the pathogenesis of severe and complicated malaria, including cytoadhesion, rosetting and PfEMP1 expression. We found that pRBCs from donors with

• In the present study we aimed at integrating single

  2018-11-07

  

  In the present study we aimed at integrating single cell properties and network activity in dissociated cultures of Ts65Dn and Tc1 mouse models and in their respective diploid cultures. We report here that network activity was reduced and that trisomic neurons were less excitable due to an increase

• br Authors Contributions br Declaration of Interests br Ethi

  2018-11-07

  

  Authors\' Contributions Declaration of Interests Ethics Committee Approval Acknowledgements SCa is partly funded by ANR grant no. ANR-11-DPBS-0002. The DEFI study was supported by a national program for clinical research (PHRC 2005) (AOM05018) and by the National Centre for Hereditary

• The ZIKV field is still developing and critics regarding the

  2018-11-07

  

  The ZIKV field is still developing, and critics regarding the use of the original ZIKV strain are starting to emerge. There is currently no appropriate African and Asian reference strains to allow proper comparison of results between laboratories. At this stage, we cannot disregard that the differe

• The utility of newborn TSH and OHP levels in addition

  2018-11-07

  

  The utility of newborn TSH and 17-OHP levels in addition to Hb ratios in model performance was also explored. Similar to hemoglobin, TSH and 17-OHP offer practical advantages as they may be routinely obtained by fluorometric or colorimetric assay rather than by mass spectrometry analysis. These anal

• br Material and Methods br Results br Discussion Here

  2018-11-07

  

  Material and Methods Results Discussion Here we describe a central tumor-promoting role for CPSF6 in luminal B, HER2-overexrepressing and TNBC subtypes associated with poor patient outcome. CPSF6 was found to be part of the pan-cancer pro-oncogenic A-to-I RNA editing machinery through inter

• br Acknowledgments The SAXS data collection was

  2018-11-07

  

  Acknowledgments The SAXS data collection was done at the DND-CAT at the Advanced Photon Source Science User Facility operated for the U.S. Department of Energy (DOE), supported by the U.S. DOE under Contract no. DE-AC02-06CH11357. This project has been funded with Federal funds from the National

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