• sirtuin inhibitors br Discussion Chronic myelogenous leukemi

  2019-04-23

  

  Discussion Chronic myelogenous leukemia (CML) is a clonal disorder involving the pluripotent stem cell and is consistently associated with the BCR-ABL1 fusion gene located on the Philadelphia chromosome [1]. The disease typically evolves in 3 distinct clinical stages: chronic and accelerated phas

• br A new model of human wellbeing

  2019-04-23

  

  A new model of human wellbeing is emerging to guide humanity in the Anthropocene. In essence, it recognises that wellbeing depends on enabling every person to lead a life of dignity and opportunity, while safeguarding the integrity of Earth\'s life-supporting systems. The conceptual framework of s

• CLL associated HLH was first

  2019-04-22

  

  CLL associated HLH was first documented in the form of a case series report which included six patients treated for CLL who subsequently developed the phagocytic syndrome months to years later.[7] As these cases occurred prior to publication of the 1991 HLH diagnostic guidelines, the authors postula

• br Interpretation of identified genetic variants

  2019-04-22

  

  Interpretation of identified genetic variants and genetic counseling Although the current expert consensus statement recommends that comprehensive or BrS1 (SCN5A) targeted BrS genetic testing can be useful for genetic testing [63], not all the published SCN5A mutations in BrS have been subjected

• br Discussion br Conclusions br Conflicts of

  2019-04-22

  

  Discussion Conclusions Conflicts of interest Introduction Catecholaminergic polymorphic ventricular tachycardia (CPVT) is induced by emotional stress or exercise in patients without organic heart disease and may be polymorphic or bidirectional (Fig. 1) [1–3]. This ventricular arrhythmia

• br Results and discussion br Authorship contributions

  2019-04-22

  

  Results and discussion Authorship contributions Conflict of interest Acknowledgments This work is supported by grants from the United States National Institutes of Health/National Cancer Institute: R01 CA098472 and R01 CA170334. We thank Dr. Dan Zhang and Andy Awwad for technical assista

• br Introduction Acute myeloid leukemia AML remains a hematol

  2019-04-22

  

  Introduction Acute myeloid leukemia (AML) remains a hematologic malignancy with poor outcome and a high risk for relapse believed to be caused by the survival of leukemic stem cells (LSCs), which are responsible for disease repopulation following treatment [1]. This important implication of LSCs

• Although high and variable frequencies of sickle

  2019-04-22

  

  Although high and variable frequencies of sickle cell trait in different ethnic groups in Uganda have been reported previously, those data were from around 70 years ago and were based on small sample sizes. Thus, the findings of Ndeezi and colleagues provide a contemporary overview that is nationall

• br Efforts to address malnutrition maternal and

  2019-04-22

  

  Efforts to address malnutrition, maternal and child mortality, and other global health priorities are heavily reliant on behaviour change, including adoption and correct use of health technology, and following treatment recommendations. One long-standing concern is the limited effectiveness of man

• MiR a rs is situated in the passenger strand

  2019-04-22

  

  MiR-196a2 rs11614913 is situated in the 3′ passenger strand mature sequence of miR-196a2. The C to T mutation of the rs11614913 SNP, which was located in the stem region of an miR-196a-2 precursor, leads to a change from a G:C to a G:U mismatch. A previous study has shown that miR-196a2 rs11614913 c

• br Material and methods br Results

  2019-04-22

  

  Material and methods Results Discussion ES-SCLC is a disease with poor prognosis. Treatment outcome has not improved significantly during the last decades despite great efforts have been made. Maintenance therapy has been tried in several clinical trials with the aim to prevent the onset of

• MM-102 Una participaci n de particular relevancia fue la de

  2019-04-20

  

  Una participación de particular relevancia fue la de Hugo Chávez en el Fsm 2006, pues su discurso puede considerarse una síntesis de la comprensión desde la política institucional latinoamericana de izquierdas sobre los movimientos sociales. En su discurso, Chávez convocó MM-102 la coordinación y a

• br Material and methods br Results

  2019-04-20

  

  Material and methods Results Discussion Conclusion Financial support Conflicts of interest Introduction Metabolic syndrome comprises a cluster of conditions, including obesity, insulin resistance, hypertension, and abnormal cholesterol levels, which together increase cardiovascu

• Early repolarization ER is characterized by elevation

  2019-04-20

  

  Early repolarization (ER) is characterized by elevation of the QRS-ST junction (J point) and QRS notching or slurring (J wave) in multiple leads, especially the inferior and/or left precordial leads. Although this finding has been considered to be a benign ECG manifestation, Haïssaguerre et al repor

• The appearance of J wave or ER is now

  2019-04-20

  

  The appearance of J wave or ER is now recognized to predispose to the development of arrhythmogenesis when associated with other cardiac disorders, such as ischemia, Phos-tag Acrylamide failure, and hypothermia. The J wave might predict prognosis of cardiac events in various heart diseases, and the

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