• The concept of hematopoietic stem cells More than a century

  2018-10-22

  

  The concept of hematopoietic stem cells: More than a century ago The development of cell biology research coincides with the advance of microscopes in the 19th century. It was finally possible to directly observe the various blood cell types and to witness their proliferation and differentiation (M

• In the present study we isolated defined populations of ASC

  2018-10-22

  

  In the present study, we isolated defined populations of ASC from human abdominal subcutaneous fat tissue derived from 4 different women. The immunophenotype and the in vitro differentiation capacity of these s6 kinase were analyzed after expansion in medium with low concentrations of FBS until pas

• Several pancreatic cancer cell lines and human tissue sample

  2018-10-22

  

  Several pancreatic cancer cell lines and human tissue samples were surveyed for cell surface, intracellular, and functional markers. CD20, CD24, CD44, CD133, CD184 (CXCR4), CD326 (EpCam), Sox-2, and OCT3/4 were examined in established pancreatic cancer cell lines. The functional marker, i.e., SP, wa

• br Materials and methods br Results br Discussion

  2018-10-22

  

  Materials and methods Results Discussion The mechanisms of ADSC migration are still largely unknown. Migration of ADSCs in vitro is shown to be induced by several chemokines, VEGF, PDGF, LPA and TxA2 through activation of their biologically active receptors (Amos et al., 2008; Baek et al.,

• br Materials and methods br Results

  2018-10-22

  

  Materials and methods Results Discussion Currently, a number of cell types such as EPCs, bone marrow mononuclear cells, and mesenchymal stromal 740 Y-P Supplier are being tested in clinical trials for their efficacy in treating cardiovascular diseases (O\'Neill et al., 2012). Although ther

• PSCs exhibit an unusual mode of

  2018-10-22

  

  PSCs exhibit an unusual mode of cell-cycle regulation with a truncated G1 and a large percentage of S phase cells (Singh and Dalton, 2009). As PSCs differentiate, the GSK503 is remodeled, such that G1 is lengthened and the relative amount of time associated with S phase cells is reduced. Recent rep

• br Experimental Procedures br Author Contributions br Introd

  2018-10-22

  

  Experimental Procedures Author Contributions Introduction Just as the circulatory system provides nourishment to support tissue and organ function, the larger blood vessels themselves require access to a blood supply to maintain vascular health. The vasa vasorum (Latin: “vessels of the vess

• According to these roles in the developing cerebellum we

  2018-10-22

  

  According to these roles in the developing cerebellum, we show that ASCL1 and NEUROG2 reprogram CerebAstro mostly into GABAergic iNs. Moreover, expression of calcium binding proteins reveals that ASCL1 and NEUROG2 lineage-reprogrammed CerebAstro iNs are distinct: while ASCL1 induces mostly CALBINDIN

• br Disclosure of potential conflicts

  2018-10-22

  

  Disclosure of potential conflicts of interests The following are the supplementary data related to this article. Acknowledgment We gratefully acknowledge the support from the National Natural Science Foundation of China (81070967; 81271338), the Natural Science Foundation of Jiang Su Province

• The following are the supplementary data related to

  2018-10-22

  

  The following are the supplementary data related to this article. Acknowledgments We thank Kati Hansen and Robert Kuhnert for excellent technical assistance and Rolf Kemler for helpful discussions and sharing reagents. We are grateful to Benoît Kanzler and Caroline Johner from the transgenic and

• br Materials and methods br Results br Discussion Microglia

  2018-10-20

  

  Materials and methods Results Discussion Microglia are resident immune ccr5 antagonist in the CNS that regulate innate immunity and participate in adaptive immune response (Hanisch and Kettenmann, 2007). However, the roles of microglia in AD pathology are still under debate. While there is

• br Materials and methods br Resource table br

  2018-10-20

  

  Materials and methods Resource table. Resource details Fanconi anemia (FA) is caused by genetic defects in the Fanconi anemia pathway (FA-pathway), which is involved in DNA inter-strand cross-link repair. The disease is characterized by progressive bone marrow failure with a significant num

• The following are the supplementary data

  2018-10-20

  

  The following are the supplementary data related to this article. Introduction Mammalian hematopoiesis is a dynamic process that is regulated spatially and temporarily through embryonic development (Baron and Fraser, 2005; Godin and Cumano, 2002; Palis et al., 1995). In mouse embryos, the initia

• Based on our results we propose

  2018-10-20

  

  Based on our results, we propose a panel of potential hiPSC protein markers from the above-mentioned 22 proteins (Supplementary Table 12). We intentionally used three previously characterized stem cell lines (hiPSC: iNC-01, SB5-MP1 and hESC-H9) in our proteomic study. The genomic methylation profile

• The goals of this study were

  2018-10-20

  

  The goals of this study were to evaluate if human fetal gallbladder contains a clonogenic candidate stem cell population and compare its phenotypic and expression profiles to those of fetal IHBD cells. The evaluation of human fetal gallbladder stem E-4031 would have important ramifications for the

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