• Optical coherence tomography angiography is another promisin

  2024-11-15

  

  Optical coherence tomography angiography is another promising method for the assessment of corneal neovascularization. This relatively new modality is not yet widely used in part because of current limitations in the definition of images produced, lack of functional information, and inability to det

• Natural compounds present in medicinal and

  2024-11-15

  

  Natural compounds, present in medicinal and/or nutritional plants as well as in macrofungi sources, have stimulated a great interest from the pharmaceutical industry. Different natural compounds such as phenolic compounds, alkaloids, terpenoids among others, have shown strong antiangiogenic effects

• br Acknowledgments and Disclosures br Alzheimer s disease as

  2024-11-15

  

  Acknowledgments and Disclosures Alzheimer's disease as a synaptic pathology Alzheimer's disease (AD) is a chronic neurodegenerative bacteriological disorder and the most common cause of dementia in the elderly. Progressive depositions of amyloid plaques and neurofibrillary tangles together wi

• We have recently begun to demonstrate

  2024-11-15

  

  We have recently begun to demonstrate this concept by reporting a novel class of β-hairpin peptidomimetics, built on a piperidine-pyrrolidine semi-rigid β-turn inducer [12] and bearing two recognition pentapeptide sequences, designed on oligomeric and fibril structures of Aβ1-42 (compound 1, Fig. 1)

• br Materials and methods br Conflict of interest br

  2024-11-15

  

  Materials and methods Conflict of interest Acknowledgments We thank Christine Heiner (Department of Surgery, University of Pittsburgh) for her critical reading of the manuscript. This work was supported by grants from the US National Institutes of Health (R01GM115366, R01CA160417, and R01CA

• Similarly results obtained in our lab using

  2024-11-15

  

  Similarly, results obtained in our lab using experimental diabetic encephalopathy induced by streptozotocin (STZ) in C57BL-6 mice showed that the hippocampus of the diabetic animals exhibited reactive gliosis, neuronal loss, NF-kB signaling activation as well as high levels of IL-1β and vascular end

• SU11274 br Polymorphic variation ERAP is polymorphic and sev

  2024-11-15

  

  Polymorphic variation ERAP1 is polymorphic and several single nucleotide polymorphisms (SNPs) in its gene that encode amino SU11274 changes have been associated with predisposition to a variety of diseases, ranging from viral infections to cancer and autoimmunity (Alvarez-Navarro and Lopez de Ca

• br Polymorphic variation ERAP is polymorphic and several sin

  2024-11-15

  

  Polymorphic variation ERAP1 is polymorphic and several single nucleotide polymorphisms (SNPs) in its gene that encode amino SC75741 changes have been associated with predisposition to a variety of diseases, ranging from viral infections to cancer and autoimmunity (Alvarez-Navarro and Lopez de Ca

• br The lipoxygenase pathway in vascular

  2024-11-15

  

  The 12/15-lipoxygenase pathway in vascular physiology and pathology The mammalian 12- and 15-LOXs have high substrate specificity oxidizing predominantly ω−6 (arachidonic and linoleic acids) but also the ω−3 (docosahexanoic) ODQ [86], [87], [88]. Different LOXs oxidize fatty acids both in the fr

• br Discussion Herein we demonstrate that mice

  2024-11-15

  

  Discussion Herein, we demonstrate that mice deficient in L-12/15 LO are more sensitive to 3-NP-induced toxicity although a substantial individual variability in striatal lesion size in response to 3-NP in both genotypes was observed. This variability is not atypical; several studies demonstrate s

• br Materials and methods br Results br

  2024-11-15

  

  Materials and methods Results Discussion The novel and central finding of the current study is that endothelial 12/15-LO rather than the monocytic/macrophagic 12/15-LO has a critical role in hyperglycemia-induced leukocyte adhesion and retinal endothelial barrier dysfunction. The following

• Some of the earliest LOX inhibitors

  2024-11-15

  

  Some of the earliest 12-LOX inhibitors were redox inhibitors, including nordihydroguaiaretic ezh2 pathway (NDGA), BW 755C, and baicalein 48, 49, 50. Redox inhibitors block the oxidation of the nonheme iron at the cataylytic site, preventing its conversion from the inactive (Fe2+) to the active (Fe3

• br Conclusion br Conflicts of interest br Introduction Alzhe

  2024-11-15

  

  Conclusion Conflicts of interest Introduction Alzheimer’s disease is the most common neurodegenerative condition known to cause dementia (Ferri et al., 2005). Alzheimer’s dementia typically presents with initial recent episodic memory deficits, word finding difficulty and later with apraxia

• Introduction Epinephrine is an endocrine hormone mainly prod

  2024-11-15

  

  Introduction Epinephrine is an endocrine hormone mainly produced by adrenal medulla in response to stress (Tank and Lee Wong, 2015). This catecholamine exerts various major physiological effects, concerning notably the cardiovascular system, the respiratory system and the endocrine system, through

• br Conclusion br Conflicts of interest

  2024-11-15

  

  Conclusion Conflicts of interest Compliance with ethical standards Introduction Tuberculosis is one of the leading causes of morbidity and mortality, amongst infectious diseases. India is a high burden country for Tuberculosis. Caused by Mycobacterium tuberculosis, it hoechst stain synt

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